Wednesday, June 5, 2013

Study coaxes clays to make human bone

Weak bones, broken bones, damaged bones, arthritic bones. Whether damaged by injury, disease or age, your body can't create new bone, but maybe science can. Researchers at North Dakota State University, Fargo, are making strides in tissue engineering, designing scaffolds that may lead to ways to regenerate bone. Published in the Journal of Biomedical Materials Research Part A, the research of Dr. Kalpana Katti, Dr. Dinesh Katti and graduate student Avinash Ambre includes a novel method that uses nanosized clays to make scaffolds to mineralize bone minerals such as hydroxyapatite.

The NDSU research team's 3-D mesh scaffold is comprised of degradable materials that are compatible to human tissue. Over time, the cells generate bone and the scaffold deteriorates. As indicated in the NDSU team's published scientific research from 2008 to 2013, the nanoclays enhance the mechanical properties of the scaffold by enabling scaffold to bear load while bone generates. An interesting finding by the Katti group has shown that the nanoclays also impart useful biological properties to the scaffold.

"The biomineralized nanoclays also impart osteogenic or bone-forming abilities to the scaffold to enable birth of bone," said Dr. Kalpana Katti, Distinguished Professor of civil engineering at NDSU. "Although it would have been exciting to say that this finding had a 'Eureka moment,' this discovery was a methodical exploration of simulations and modeling, indicating that amino acid modified nanoclays are viable new nanomaterials," said Katti. The work was initially published in the Journal of Biomacromolecules in 2005. The current findings point toward the potential use of....

Read complete article
Subscribe to NBIC News